Research focuses on the molecular and cellular mechanisms by which the Matrix Metalloproteinases (MMPs), enzymes that degrade the extracellular matrix at neutral pH, facilitate the invasive and metastatic behavior of tumor cells. In most normal cells, constitutive expression of MMPs is low, but increases in response to cytokines and growth factors. In some tumors (e.g., breast cancer and melanoma), however, MMP expression is constutively high, and the high expression enhances their invasiveness. This lab is using a novel invasion assay to monitor the invasion of tumor cells through the extracellular matrix and to document the efficacy of novel agents that suppress MMPs to also suppress invasion and metastasis.
AR-26599-28. Regulation of Collagenase Gene Expression CA-77267-07. Invasive Behavior of Tumor cells Producing Collagenase-1